Endocrine Abstracts

Chronic exposure to hypobaric hypoxia (HH) causes neurodegeneration and loss of memory. The underlying mechanisms of HH-induced memory impairment have been attributed to prolonged elevated corticosterone level in hippocampus leading to augmented glutamate excitotoxicity, oxidative stress, alteration of neurotransmitter level or their receptors and calcium mediated signaling. Whether this corticosterone mediated neurodegenerative effect occurs through overstimulation of glucoco...

Hypobaric hypoxia, an environmental condition arising due to the reduced partial pressure of oxygen on ascent to high altitude, is known to cause memory impairment. The mechanism underlying the cognitive dysfunction has been attributed to oxidative stress, glutamate excitotoxicity and Ca2+ mediated death cascade. Though the role of corticosterone in higher order brain function including cognition has been well documented in restrained stress, social stress and other...